Early Detection of Recurrence of Ovarian Cancer using Telomerase Assay in Peritoneal Washing Fluids

( 最大 2000 件 )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/5753
タイトル
Early Detection of Recurrence of Ovarian Cancer using Telomerase Assay in Peritoneal Washing Fluids
ファイル
内容記述

OBJECTIVE: The aim of this study was to evaluate whether telomerase activity in peritoneal washing fluids can be used as novel means for early detection of the recurrence of ovarian cancer.
METHODS : Twenty patients with ovarian cancer (stage 1c i n 2,I ai n 2,I ci n 2,i lla in 2,illb in 1,illc in 4, and N in 7) were recruited for the study. These patients received maximal debu-Iking as a primary treatment, and were followedup using telomerase activity measurement σRAP assay) and cytological examination in peritoneal washing fluids.
RESULTS: In 8 patients with telomerase negative and negative peritoneal washing cytology, no recurrence was ascertained. Of the 6 peritoneal washing cytology negative cases,3 were telomerase positive. When these 3 were reevaluated for peritoneal cytology, malignant ascites were identified in all3 patients later. Of the 12 patients with telomerase positive, 9 died, whereas none died in 8 patients with telomerase negative (p<O.005). Patients with telomerase positive had significantly poorer outcomes than those with telomerase negative (p<O.005).
CONCLUSIONS: Our preliminary results reveal that the telomerase test in peritoneal washing fluids can be used as an adjuvant to cytopathological methods in early detection of the recurrence of ovarian cancer. Our results suggest that positive telomerase activity in peritoneal washing fluids may indicate the poor prognostic factor in patients with ovarian cancer.

著者
著者 Ohno Masayuki
著者(ヨミ) オオノ マサユキ
著者(別表記) 大野 正文
著者 Kanenishi Kenji
著者(ヨミ) カネニシ ケンジ
著者(別表記) 金西 賢治
著者 Igarashi Tatsuya
著者(ヨミ) イガラシ タツヤ
著者(別表記) 五十嵐 達也
著者 Shiota Atsuko
著者(ヨミ) シオタ アツコ
著者(別表記) 塩田 敦子
著者 Hata Toshiyuki
著者(ヨミ) ハタ トシユキ
著者(別表記) 秦 利之
掲載誌
日本産科婦人科学会香川地方部会雑誌
掲載誌(別表記)
Kagawa journal of obstetrics and gynecology
7
1
開始ページ
35
終了ページ
39
出版者
日本産科婦人科学会香川地方部会
出版年月日
200509
ISSN
1345-9686
NCID
AA11572125
資料タイプ
紀要論文
言語
英語
出版社版
区分
香川大学
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