Innovative methods using circulating tumor cells for prediction of the effects of induction therapy on locally advanced non-small cell lung cancer

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27460
Title
Innovative methods using circulating tumor cells for prediction of the effects of induction therapy on locally advanced non-small cell lung cancer
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Description

Abstract
BACKGROUND:

The existence of circulating tumor cells (CTCs) in patients with lung cancer has been reported. The purpose of this study was to assess whether CTCs are predictive of the pathological effects of induction chemoradiotherapy for patients with non-small cell lung cancer.
METHODS:

Patients who underwent induction chemoradiotherapy followed by surgery were compared with those who underwent surgery alone. Peripheral and pulmonary venous blood samples from the involved lobe were collected intraoperatively, and the number of CTCs was counted using the CellSearch™ system, an epithelial cell adhesion molecule-based immunomagnetic technique.
RESULTS:

Of the 9 patients who underwent induction therapy, 4 achieved pathological CR, 4 achieved major response, and 1 achieved minor response. All patients who underwent induction therapy and surgery alone were negative for CTCs in peripheral blood. In the induction therapy group, 4 patients showing pathological CR were negative for CTCs in pulmonary venous blood (pvCTCs) and 5 showing major/minor response were positive (mean, 57.8 cells). The numbers of CTCs in patients showing major/minor response were significantly higher than those in patients showing pathological CR (p = 0.012, Mann-Whitney U test). All 6 patients undergoing surgery alone were positive for pvCTCs (mean, 207.5 cells), showing a significant difference from those undergoing induction therapy (p = 0.038).
CONCLUSIONS:

The existence of CTCs in pulmonary venous blood reflects pathological non-CR, and therapeutic pathological response may be predicted by pvCTC measurement.

(医博甲577)

Author
著者 垂水 晋太郎
著者(ヨミ) タルミ シンタロウ
著者(別表記) Tarumi Shintaro
Publication Title
Journal of Cardiothoracic Surgery
Publication Title Alternative
J Cardiothorac Surg.
Volume
8
Start Page
175
End Page
175
Publisher
BMC (part of Springer Nature)
Published Date
2013-07-16
ISSN
1749-8090
PMID
23856305
DOI
10.1186/1749-8090-8-175
Resource Type
Thesis or Dissertation
Language
eng
Relation
PMCID: PMC3718657
Resource URL
https://doi.org/10.1186/1749-8090-8-175
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718657/
Rights
Copyright © 2013 Tarumi et al.; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Publisher's Version DOI: https://doi.org/10.1186/1749-8090-8-175
Text Version
ETD
Grant ID
博甲第577号
Grant Date
2013-12-26
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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