Vimentin regulates the invasiveness and is a poor prognostic marker in non-small cell lung cancer

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/27851
タイトル
Vimentin regulates the invasiveness and is a poor prognostic marker in non-small cell lung cancer
ファイル
内容記述

Abstract
BACKGROUND:

Lung cancer cells often express vimentin. However, the function of vimentin in lung cancer cells has not been fully evaluated.
MATERIALS AND METHODS:

We evaluated the association between vimentin expression in resected non-small cell lung cancer (NSCLC) specimens and prognosis. Short-interfering RNA targeting vimentin and establishment of an invasive cell line by repeated selection of invasive cells using a Matrigel membrane invasion chamber system (MICS) were performed. MICS was used to reveal the relationship between invasiveness and vimentin.
RESULTS:

Vimentin positivity was significantly associated with a poor prognosis and was significantly lower in squamous cell carcinoma than in adenocarcinoma. In in vitro experiments, silencing of vimentin reduced invasiveness. Highly invasive cell lines exhibited higher expression of vimentin than did parental cells, and invasive ability was reduced by knockdown of vimentin.
CONCLUSION:

Vimentin expression is associated with prognosis via alteration of the invasive ability of NSCLC cells.

KEYWORDS:

Lung cancer; invasion; prognosis; vimentin

著者
著者 田所 明
著者(ヨミ) タドコロ  アキラ
著者(別表記)
掲載誌
Anticancer Research
36
4
開始ページ
1545
終了ページ
1551
出版者
International Institute of Anticancer Research
出版年月日
2016-04-01
ISSN
0250-7005
PMID
27069130
資料タイプ
学位論文
言語
英語
博士論文(全文を含む)
学位授与番号
博甲第639号
学位授与年月日
2016-6-28
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
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