Metamorphopsia associated with central retinal vein occlusion

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28454
Title
Metamorphopsia associated with central retinal vein occlusion
File
Description

Abstract

This prospective study aimed to investigate metamorphopsia in eyes with central retinal vein occlusion (CRVO) and included 28 eyes (28 patients) with unilateral CRVO that had macular edema (ME) in the acute phase. The ME was treated with anti-vascular endothelial growth factor agents. At baseline and at 1 and 6 months after initiation of treatment, quantitative measurements of metamorphopsia were performed using M-CHARTS and the retinal morphologic changes were examined by optical coherence tomography. At baseline, metamorphopsia was detected on M-CHARTS in 14 (50.0%) eyes. The mean M-CHARTS score was 0.37 ± 0.53. At 1 month and 6 months after initiation of treatment, there was substantial resolution of ME and significant recovery of visual acuity. In contrast, metamorphopsia was still detected in 16 eyes at 6 months; the mean M-CHARTS scores were 0.29 ± 0.37 at 1 month and 0.32 ± 0.38 at 6 months, and had not significantly improved from baseline (p = 0.580, and p = 0.604, respectively). Although the M-CHARTS score at 6 months was associated with the baseline M-CHARTS score (p = 0.004), it did not have any associations with morphologic parameters at baseline. However, the M-CHARTS score at 6 months was significantly associated with foveal photoreceptor status, height of serous detachment, and parafoveal thickening at 1 month. Metamorphopsia associated with CRVO could be quantified using M-CHARTS, and often persisted in contrast with the recovery of visual acuity and resolution of ME after treatment with anti-vascular endothelial growth factor agents.

(医博甲684)

Author
著者 真鍋 耕一郎
著者(ヨミ) マナベ コウイチロウ
著者(別表記) Manabe Koichiro
Publication Title
PLoS ONE
Publication Title Alternative
PLoS One.
Volume
12
Issue
10
Start Page
e0186737
End Page
e0186737
Publisher
Public Library of Science
Published Date
2017-10-19
ISBN
1932-6203
PMID
29049410
DOI
10.1371/journal.pone.0186737
Resource Type
Thesis or Dissertation
Language
eng
Relation
出版社版DOIリンク(URL): https://doi.org/10.1371/journal.pone.0186737
PMCID:PMC5648234
Resource URL
https://doi.org/10.1371/journal.pone.0186737
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648234/
Rights
出版社の著作権ポリシーにより、論文の本文は、「クリエイティブ・コモンズ 表示 4.0 国際 ライセンス」(CC-BY 4.0)で提供されます。 / Depending on the copyright policy of the publisher, the body of the paper is provided in Creative Commons Attribution 4.0 international license (CC-BY 4.0).
著者は著作権を保持します。 / Authors retain copyright
Copyright © 2017 Manabe et al
DOI: https://doi.org/10.1371/journal.pone.0186737
Text Version
ETD
Grant ID
博甲第684号
Grant Date
2018-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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