Metamorphopsia associated with central retinal vein occlusion

( 最大 2000 件 )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28454
タイトル
Metamorphopsia associated with central retinal vein occlusion
ファイル
内容記述

Abstract

This prospective study aimed to investigate metamorphopsia in eyes with central retinal vein occlusion (CRVO) and included 28 eyes (28 patients) with unilateral CRVO that had macular edema (ME) in the acute phase. The ME was treated with anti-vascular endothelial growth factor agents. At baseline and at 1 and 6 months after initiation of treatment, quantitative measurements of metamorphopsia were performed using M-CHARTS and the retinal morphologic changes were examined by optical coherence tomography. At baseline, metamorphopsia was detected on M-CHARTS in 14 (50.0%) eyes. The mean M-CHARTS score was 0.37 ± 0.53. At 1 month and 6 months after initiation of treatment, there was substantial resolution of ME and significant recovery of visual acuity. In contrast, metamorphopsia was still detected in 16 eyes at 6 months; the mean M-CHARTS scores were 0.29 ± 0.37 at 1 month and 0.32 ± 0.38 at 6 months, and had not significantly improved from baseline (p = 0.580, and p = 0.604, respectively). Although the M-CHARTS score at 6 months was associated with the baseline M-CHARTS score (p = 0.004), it did not have any associations with morphologic parameters at baseline. However, the M-CHARTS score at 6 months was significantly associated with foveal photoreceptor status, height of serous detachment, and parafoveal thickening at 1 month. Metamorphopsia associated with CRVO could be quantified using M-CHARTS, and often persisted in contrast with the recovery of visual acuity and resolution of ME after treatment with anti-vascular endothelial growth factor agents.

(医博甲684)

著者
著者 真鍋 耕一郎
著者(ヨミ) マナベ コウイチロウ
著者(別表記) Manabe Koichiro
掲載誌
PLoS ONE
掲載誌(別表記)
PLoS One.
12
10
開始ページ
e0186737
終了ページ
e0186737
出版者
Public Library of Science
出版年月日
2017-10-19
ISBN
1932-6203
PMID
29049410
DOI
10.1371/journal.pone.0186737
資料タイプ
学位論文
言語
英語
関連情報
出版社版DOIリンク(URL): https://doi.org/10.1371/journal.pone.0186737
PMCID:PMC5648234
関連情報URL
https://doi.org/10.1371/journal.pone.0186737
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648234/
権利関係
出版社の著作権ポリシーにより、論文の本文は、「クリエイティブ・コモンズ 表示 4.0 国際 ライセンス」(CC-BY 4.0)で提供されます。 / Depending on the copyright policy of the publisher, the body of the paper is provided in Creative Commons Attribution 4.0 international license (CC-BY 4.0).
著者は著作権を保持します。 / Authors retain copyright
Copyright © 2017 Manabe et al
DOI: https://doi.org/10.1371/journal.pone.0186737
博士論文(全文を含む)
学位授与番号
博甲第684号
学位授与年月日
2018-03-24
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
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