Effects of galectin-9 on apoptosis, cell cycle and autophagy in human esophageal adenocarcinoma cells

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28457
Title
Effects of galectin-9 on apoptosis, cell cycle and autophagy in human esophageal adenocarcinoma cells
File
Description

Abstract

The incidence of esophageal adenocarcinoma (EAC) is rapidly increasing in western countries. The overall mortality of this disease remains high with a 5-year survival rate of less than 20%, despite remarkable advances in the care of patients with EAC. Galectin-9 (Gal-9) is a tandem-repeat type galectin that exerts anti-proliferative effects on various cancer cell types. The aim of the present study was to evaluate the effects of Gal-9 on human EAC cells and to assess the expression of microRNAs (miRNAs) associated with the antitumor effects of Gal-9 in vitro. Gal-9 suppressed the proliferation of the EAC cell lines OE19, OE33, SK-GT4, and OACM 5.1C. Additionally, Gal-9 treatment induced apoptosis and increased the expression levels of caspase-cleaved cytokeratin 18, activated caspase-3 and activated caspase-9. However, it did not promote cell cycle arrest by reducing cell cycle-related protein levels. Furthermore, Gal-9 increased the level of the angiogenesis-related protein interleukin-8 (IL-8) and markedly altered miRNA expression. Based on these findings, Gal-9 may be of clinical use for the treatment of EAC.

Author
著者 明石 瑛美子
著者(ヨミ) アカシ エミコ
著者(別表記)
Publication Title
Oncology Reports
Volume
38
Issue
1
Start Page
506
End Page
514
Publisher
Spandidos Publications
Published Date
2017-06-01
ISSN
1021-335X
PMID
28586026
DOI
10.3892/or.2017.5689
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
出版社版DOIリンク(URL) : https://doi.org/10.3892/or.2017.5689
Text Version
ETD
Grant ID
博甲第687号
Grant Date
2018-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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