Effects of galectin-9 on apoptosis, cell cycle and autophagy in human esophageal adenocarcinoma cells

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28457
タイトル
Effects of galectin-9 on apoptosis, cell cycle and autophagy in human esophageal adenocarcinoma cells
ファイル
内容記述

Abstract

The incidence of esophageal adenocarcinoma (EAC) is rapidly increasing in western countries. The overall mortality of this disease remains high with a 5-year survival rate of less than 20%, despite remarkable advances in the care of patients with EAC. Galectin-9 (Gal-9) is a tandem-repeat type galectin that exerts anti-proliferative effects on various cancer cell types. The aim of the present study was to evaluate the effects of Gal-9 on human EAC cells and to assess the expression of microRNAs (miRNAs) associated with the antitumor effects of Gal-9 in vitro. Gal-9 suppressed the proliferation of the EAC cell lines OE19, OE33, SK-GT4, and OACM 5.1C. Additionally, Gal-9 treatment induced apoptosis and increased the expression levels of caspase-cleaved cytokeratin 18, activated caspase-3 and activated caspase-9. However, it did not promote cell cycle arrest by reducing cell cycle-related protein levels. Furthermore, Gal-9 increased the level of the angiogenesis-related protein interleukin-8 (IL-8) and markedly altered miRNA expression. Based on these findings, Gal-9 may be of clinical use for the treatment of EAC.

著者
著者 明石 瑛美子
著者(ヨミ) アカシ エミコ
著者(別表記)
掲載誌
Oncology Reports
38
1
開始ページ
506
終了ページ
514
出版者
Spandidos Publications
出版年月日
2017-06-01
ISSN
1021-335X
PMID
28586026
DOI
10.3892/or.2017.5689
資料タイプ
学位論文
言語
英語
関連情報URL
出版社版DOIリンク(URL) : https://doi.org/10.3892/or.2017.5689
博士論文(全文を含む)
学位授与番号
博甲第687号
学位授与年月日
2018-03-24
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
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