Identification of microRNA profiles associated with refractory primary biliary cirrhosis

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28460
Title
Identification of microRNA profiles associated with refractory primary biliary cirrhosis
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Description

Abstract

MicroRNAs (miRNAs) are small, endogenous, non-coding RNAs that control the target gene translation by RNA interference; miRNAs are associated with cellular processes, including proliferation, differentiation, apoptosis, and cell survival. Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease of unknown etiology. One third of patients with PBC demonstrate suboptimal responses, which result in worse outcomes. It has been previously reported that miRNAs are involved in drug resistance, however, the association between miRNA expression levels and refractory PBC remains to be fully elucidated. In the present study, among the 20 patients with PBC treated with ursodeoxycholic acid or bezafibrate, 15 patients were classed as treatment‑effective, and 5 were classed as being treatment‑resistant. Using the miRNA array technique, miRNA profiles were identified for each group. A total of 35 miRNAs were significantly upregulated, and 23 were significantly downregulated in the treatment‑resistant group compared with the treatment‑effective group. In order to examine the association between the highly altered miRNAs and clinical features of the two groups, numerous parameters were analyzed. Elevated levels of direct bilirubin, aspartate transaminase (AST), and alanine transaminase (ALT) were identified to be associated with miRNA‑122 upregulation. AST, ALT, and γ guanosine triphosphate were additionally associated with miRNA‑378f upregulation. However, the reduction of miRNA‑4311 was associated with reduced levels of AST and ALT. miRNA‑4714‑3p was also negatively correlated with total bilirubin and lactate dehydrogenase. Therefore, identifying the miRNA profile was demonstrated to be a useful approach in the characterization of PBC development. It is suggested that highly altered miRNAs may be potential biomarkers for use in the development of treatment of patients with refractory PB

(医博甲690)

Author
著者 坂本 鉄平
著者(ヨミ) サカモト テッペイ
著者(別表記) Sakamoto Teppei
Publication Title
Molecular Medicine Reports
Publication Title Alternative
Mol Med Rep.
Volume
14
Issue
4
Start Page
3350
End Page
3356
Publisher
Spandidos Publications
Published Date
2016-08-09
ISSN
1791-2997
PMID
27511723
DOI
10.3892/mmr.2016.5606
Resource Type
Thesis or Dissertation
Language
eng
Relation
出版社版DOIリンク(URL): https://doi.org/10.3892/mmr.2016.5606
Resource URL
https://doi.org/10.3892/mmr.2016.5606
Rights
Copyright © Spandidos Publications 2016.
"This is the Publisher's version of the following article:Identification of microRNA profiles associated with refractory primary biliary cirrhosis.; Molecular Medicine Reports; Volume 14 Issue 4 (2017) 3350-3356; doi: 10.3892/mmr.2016.5606 , which has been published in final form at https://doi.org/10.3892/mmr.2016.5606 ."
DOI: https://doi.org/10.3892/mmr.2016.5606
Text Version
ETD
Grant ID
博甲第690号
Grant Date
2018-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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