The role of calcitonin gene-related peptide in migraine prevention by botulinum toxin type A

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28488
Title
The role of calcitonin gene-related peptide in migraine prevention by botulinum toxin type A
File
Description

Abstract

Objectives:
Calcitonin gene-related peptide (CGRP) is currently considered to be a major contributing factor in migraine headache. Botulinum toxin type A (BTXA) was found to be effective in migraine prevention. However, the mechanism of action in patients was unknown. Using injection as in clinical setting, the study aimed to determine whether BTXA could decrease the sensitization of the trigeminovascular nociceptive system through the reduction of CGRP action.

Methods:
Adult male Wistar rats were pretreated with normal saline solution or BTXA before KCl application to induce cortical spreading depression (CSD) or NaCl application as a control. Regional cerebral blood flow at parietal cortex was measured for 90 min after KCl or NaCl application. Tissues from trigeminal ganglion (TG) and trigeminal nucleus caudalis (TNC) were then collected for CGRP and c-Fos measurement respectively.

Results:
BTXA pretreatment significantly decreased the cumulative blood flow and number of hyperemic peaks induced by KCl. Numbers of CGRP positive cells at TG and c-Fos positive cells at TNC were also reduced by BTXA.

Conclusion:
BTXA pretreatment reduced CGRP production and release from the TG leading to lessen CSD production and persistent activation of TNC which played a major role in migraine headache.

Keywords:
Migraine, Calcitonin gene-related peptide (CGRP), botulinum toxin

(医博乙284)

Author
著者 Pleumsamran Juntima Pattamanont
著者(ヨミ) プラウムサムラン ジャンティマ パタマノン
著者(別表記)
Publication Title
Neurology Asia
Volume
23
Issue
1
Start Page
45
End Page
53
Publisher
ASEAN Neurological Association
Published Date
2018-03
ISSN
1823-6138
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://www.neurology-asia.org/articles/neuroasia-2018-23(1)-045.pdf
Relation(isVersionOf)
Publisher's Version.
Text Version
ETD
Grant ID
博乙第284号
Grant Date
2018-05-16
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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