Phenotypic characterization and clinical outcome in ampullary adenocarcinoma.

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28498
Title
Phenotypic characterization and clinical outcome in ampullary adenocarcinoma.
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Description

Abstract
BACKGROUND:

Although various features of ampullary adenocarcinoma have been reported, the impact of genetic alterations and rare subtypes on clinical outcome remains unclear.
METHODS:

We determined the expression of proteins, including MUC1, MUC2, p53, p16, Smad/Dpc4, and β-catenin, and genetic mutations such as KRAS, BRAF, and GNAS mutations in 69 patients with ampullary adenocarcinoma to clarify their relationships with clinicopathological findings and subtypes.
RESULTS:

Kaplan-Meier survival analysis indicated that abnormal p53 labeling was significantly associated with a shorter overall survival. MUC1-positive and MUC2-negative expressions were significantly associated with lymphatic invasion, pancreatic invasion, lymph node metastasis, and advanced UICC stage. The KRAS mutation was significantly associated with large tumor size and pancreatic invasion. There were 35 intestinal (50%), 15 pancreatobiliary (22%), and 11 mixed subtype (16%) tumors. Patients with the mixed subtype showed significantly poor outcome. The invasiveness of the mixed subtype was similar to that of the pancreatobiliary subtype; moreover, the mixed subtype showed a high incidence of abnormal β-catenin immunolabeling (73%).
CONCLUSIONS:

Protein expression and genetic mutation are clinically associated with the characteristics of ampullary adenocarcinoma. The mixed subtype may have a distinct tumor nature as compared to other two major subtypes.

KEYWORDS:

ampullary adenocarcinoma; mixed type; p53; pathologic subtype; β-catenin

(医博甲645)

Author
著者 浅野 栄介
著者(ヨミ) アサノ エイスケ
著者(別表記) Asano Eisuke
Publication Title
Journal of Surgical Oncology
Volume
114
Issue
1
Start Page
119
End Page
127
Publisher
Wiley-Liss
Wiley
Published Date
2016-05-02
ISSN
0022-4790
PMID
27132476
DOI
10.1002/jso.24274
Resource Type
Thesis or Dissertation
Language
eng
Relation
香川大学に提出された博士論文が、出版社版であった。Publisher's Versionは、出版社の著作権ポリシーに基づき、リポジトリへの掲載が不可能であったため、著者のAccepted Versionをリポジトリに掲載した。 The doctoral dissertation submitted to Kagawa University was a Publisher's version. Publisher's Version posted the author 's Accepted Version in the repository as it was impossible to publish in the repository based on the copyright policy of the publisher.
Relation(isVersionOf)
Apcepted Version.
Relation URL(isReplacedBy)
https://doi.org/10.1002/jso.24274
Relation(hasVersion)
Publisher's Version.
Rights
"This is the accepted version of the following article: Phenotypic characterization and clinical outcome in ampullary adenocarcinoma; Journal of Surgical Oncology;Volume 114 Number1 (2016) 119-127; doi: 10.1002/jso.24274, which has been published in final form at https://doi.org/10.1002/jso.24274 . "
Non-Commercial
12 months embargo has expired.
Text Version
ETD
Grant ID
博甲第645号
Grant Date
2016-09-29
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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