Normobaric oxygen therapy increases cartilage survival ratio in auricular composite grafting in rat models

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28574
タイトル
Normobaric oxygen therapy increases cartilage survival ratio in auricular composite grafting in rat models
ファイル
内容記述

Abstract:

Purpose: This study aims to clarify whether normobaric oxygen therapy improves the survival of auricular composite grafts in rats. Methods: For 10 male SD rats, 1.5 cm2 composite grafts were harvested from bilateral ear regions including whole auricles. The harvested grafts were transferred caudally and sutured there. The 10 rats were randomly divided into two groups and kept for 21 days in two different circumstances. The first group (Control group: five rats carrying 10 grafts) was kept in room air (20% oxygen) throughout the 21 days, and the second group―named NBO (normobaric oxygen) group (five rats carrying 10 grafts)―was kept in normobaric 60% oxygen for 3 days and then in room air for 18 days. All the 10 rats were sacrificed on the 21st day. Surviving areas of the grafts and the height of the surviving auricular cartilage were examined for statistical comparison of the two groups. Furthermore, the conditions of chondrogenesis occurring around the perichondrium were compared between the two groups. Results: Surviving areas did not present statistically significant differences between the two groups. The height of surviving cartilage was significantly greater for the NBO group (2610 ± 170 SD µm) than that for the Control group (1720 ± 190 SD µm). Chondrogenesis occurred at positions more distant from the recipient bed in the NBO group than that in the Control group. Conclusion: Normobaric oxygen therapy increases the thickness of surviving cartilage in auricular composite grafting in rats, thus suggesting that NBO therapy may also be effective in composite grafting for humans. © 2018 The Authors

Keywords:

Auricle; Blood; Cartilage; Composite graft; Ear;

(医博甲703)

著者
著者 濵本 有祐
著者(ヨミ) ハマモト ユウスケ
著者(別表記) Hamamoto Yusuke
掲載誌
JPRAS Open
18
開始ページ
28
終了ページ
37
出版者
Elsevier
出版年月日
2018-12
ISSN
2352-5878
DOI
10.1016/j.jpra.2018.07.003
資料タイプ
学位論文
言語
英語
関連情報
出版社版DOIリンク(URL): https://doi.org/10.1016/j.jpra.2018.07.003
関連情報URL
https://doi.org/10.1016/j.jpra.2018.07.003
権利関係
この博士論文の本文については、次のエルゼビアの著作権ポリシーの規定により公開しています。「博士論文の場合は、エンバーゴ期間に関係なく機関リポジトリに出版社版を公開することができます。」 The text of this doctoral dissertation is published according to the following Elsevier copyright policy. "In the case of doctoral dissertations, publishers can be published in institutional repositories regardless of the Embargo period."
OPEN Access
DOI : https://doi.org/10.1016/j.jpra.2018.07.003
博士論文(全文を含む)
学位授与番号
博甲第703号
学位授与年月日
2018-12-26
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
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