Comparison of 4'-[methyl-(11)C]thiothymidine ((11)C-4DST) and 3'-deoxy-3'-[(18)F]fluorothymidine ((18)F-FLT) PET/CT in human brain glioma imaging

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28732
Title
Comparison of 4'-[methyl-(11)C]thiothymidine ((11)C-4DST) and 3'-deoxy-3'-[(18)F]fluorothymidine ((18)F-FLT) PET/CT in human brain glioma imaging
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Description

Abstract
BACKGROUND:

3'-deoxy-3'-[(18)F]fluorothymidine ((18)F-FLT) has been used to evaluate tumor malignancy and cell proliferation in human brain gliomas. However, (18)F-FLT has several limitations in clinical use. Recently, (11)C-labeled thymidine analogue, 4'-[methyl-(11)C]thiothymidine ((11)C-4DST), became available as an in vivo cell proliferation positron emission tomography (PET) tracer. The present study was conducted to evaluate the usefulness of (11)C-4DST PET in the diagnosis of human brain gliomas by comparing with the images of (18)F-FLT PET.
METHODS:

Twenty patients with primary and recurrent brain gliomas underwent (18)F-FLT and (11)C-4DST PET scans. The uptake values in the tumors were evaluated using the maximum standardized uptake value (SUVmax), the tumor-to-normal tissue uptake (T/N) ratio, and the tumor-to-blood uptake (T/B) ratio. These values were compared among different glioma grades. Correlation between the Ki-67 labeling index and the uptake values of (11)C-4DST and (18)F-FLT in the tumor was evaluated using linear regression analysis. The relationship between the individual (18)F-FLT and (11)C-4DST uptake values in the tumors was also examined.
RESULTS:

(11)C-4DST uptake was significantly higher than that of (18)F-FLT in the normal brain. The uptake values of (11)C-4DST in the tumor were similar to those of (18)F-FLT resulting in better visualization with (18)F-FLT. No significant differences in the uptake values of (18)F-FLT and (11)C-4DST were noted among different glioma grades. Linear regression analysis showed a significant correlation between the Ki-67 labeling index and the T/N ratio of (11)C-4DST (r = 0.50, P < 0.05) and (18)F-FLT (r = 0.50, P < 0.05). Significant correlations were also found between the Ki-67 labeling index and the T/B ratio of (11)C-4DST (r = 0.52, P < 0.05) and (18)F-FLT (r = 0.55, P < 0.05). A highly significant correlation was observed between the individual T/N ratio of (11)C-4DST and (18)F-FLT in the tumor (r = 0.79, P = 0.0001).
CONCLUSIONS:

The present study demonstrates that (11)C-4DST is useful for the imaging of human brain gliomas with PET. A relatively higher background uptake of (11)C-4DST in the normal brain compared to (18)F-FLT limits the detection of low-tracer-uptake tumors. Moreover, no superiority was found in (11)C-4DST over (18)F-FLT in the evaluation of cell proliferation.

KEYWORDS:

4DST (4′-thiothymidine); Cell proliferation; FLT (fluorothymidine); Glioma; Positron emission tomography

(医博甲614)

Author
著者 豊田 康則
著者(ヨミ) トヨタ ヤスノリ
著者(別表記) Toyota Yasunori
Publication Title
EJNMMI Research
Publication Title Alternative
EJNMMI Res.
Volume
5
Start Page
7
Publisher
BMC (part of Springer Nature)
SpringerOpen (part of Springer Nature)
Published Date
2015-03-05
ISSN
2191-219X
PMID
25853013
DOI
10.1186/s13550-015-0085-3
Resource Type
Thesis or Dissertation
Language
eng
Relation
PMCID: PMC4385144
Resource URL
https://doi.org/10.1186/s13550-015-0085-3
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385144/
Rights
Copyright © Toyota et al.; licensee BioMed Central. 2015
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
Publisher's Version: https://doi.org/10.1186/s13550-015-0085-3
Text Version
ETD
Grant ID
博甲第614号
Grant Date
2015-06-25
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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