Evaluation of bilirubin displacement effect by acetaminophen in vitro

( 最大 2000 件 )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28738
タイトル
Evaluation of bilirubin displacement effect by acetaminophen in vitro
ファイル
内容記述

Abstract
BACKGROUND:

The use of acetaminophen as a drug for pain control is expected to increase in the neonatal field. The displacement factor of acetaminophen in the reaction in the glucose oxidase peroxidase method is very high, but is also considered to be inaccurate based on physicochemical properties.
METHOD:

Unbound bilirubin was measured using the erythrocyte-bound bilirubin measurement method and glucose oxidase peroxidase method by the addition of acetaminophen or sulfisoxazole. The displacement factor was measured using glucose oxidase peroxidase method with the addition of tert-butyl-p-hydroxyanisole.
RESULTS:

Acetaminophen did not increase erythrocyte-bound bilirubin, and the addition of tert-butyl-p-hydroxyanisole lowered its displacement factor. On the other hand, sulfisoxazole increased erythrocyte-bound bilirubin, while tert-butyl-p-hydroxyanisole did not change its displacement factor.
CONCLUSION:

Acetaminophen is an accelerator of the reaction in the glucose oxidase peroxidase method and does not displace bilirubin from human serum albumin.

KEYWORDS:

Erythrocyte-bound bilirubin; accelerator; glucose oxidase peroxidase method; sulfisoxazole; unbound bilirubin

(医博甲620)

著者
著者 杉野 政城
著者(ヨミ) スギノ マサシロ
著者(別表記) Sugino Masashiro
掲載誌
Annals of Clinical Biochemistry
掲載誌(別表記)
Ann Clin Biochem.
52
4
開始ページ
476
終了ページ
480
出版者
Association for Clinical Biochemistry
SAGE Publications
出版年月日
2014-12-18
ISSN
0004-5632
NCID
AA00532333
PMID
25525256
DOI
10.1177/0004563214567477
資料タイプ
学位論文
言語
英語
関連情報URL
https://doi.org/10.1177/0004563214567477
権利関係
© The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
"This is the Accepted version of the following article: Evaluation of bilirubin displacement effect by acetaminophen in vitro; Annals of Clinical Biochemistry; Volume 52 Number Pt 4 (2014) Pages:476-480; doi: 10.1177/0004563214567477, which has been published in final form at https://doi.org/10.1177/0004563214567477 . "
Publisher's Version with DOI: https://doi.org/10.1177/0004563214567477
博士論文(全文を含む)
学位授与番号
博甲第620号
学位授与年月日
2016-03-24
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
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