Effect of Dipeptidyl Peptidase-4 Inhibition on Circadian Blood Pressure during the Development of Salt-Dependent Hypertension in Rats

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Title
Effect of Dipeptidyl Peptidase-4 Inhibition on Circadian Blood Pressure during the Development of Salt-Dependent Hypertension in Rats
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Description

Abstract

A growing body of evidence has indicated that dipeptidyl peptidase-4 (DPP-4) inhibitors have antihypertensive effects. Here, we aim to examine the effect of vildagliptin, a DPP-4-specific inhibitor, on blood pressure and its circadian-dipping pattern during the development of salt-dependent hypertension in Dahl salt-sensitive (DSS) rats. DSS rats were treated with a high-salt diet (8% NaCl) plus vehicle or vildagliptin (3 or 10 mg kg(-1) twice daily by oral gavage) for 7 days. Blood pressure was measured by the telemetry system. High-salt diet for 7 days significantly increased the mean arterial pressure (MAP), systolic blood pressure (SBP) and were also associated with an extreme dipping pattern of blood pressure in DSS rats. Treatment with vildagliptin dose-dependently decreased plasma DPP-4 activity, increased plasma glucagon-like peptide 1 (GLP-1) levels and attenuated the development of salt-induced hypertension. Furthermore, vildagliptin significantly increased urine sodium excretion and normalized the dipping pattern of blood pressure. In contrast, intracerebroventricular infusion of vildagliptin (50, 500 or 2500 μg) did not alter MAP and heart rate in DSS rats. These data suggest that salt-dependent hypertension initially develops with an extreme blood pressure dipping pattern. The DPP-4 inhibitor, vildagliptin, may elicit beneficial antihypertensive effects, including the improvement of abnormal circadian blood pressure pattern, by enhancing urinary sodium excretion.

(医博乙272)

Author
著者 MD. ABU SUFIUN
著者(ヨミ) エムディ アブ スフィアン
著者(別表記) Abu Sufiun
Publication Title
Hypertension Research
Publication Title Alternative
Hypertens Res.
Volume
38
Issue
4
Start Page
237
End Page
243
Publisher
Japanese Society of Hypertension
日本高血圧学会
Springer Nature
Published Date
2015-01-15
ISSN
0916-9636
NCID
AA10847079
PMID
25588850
DOI
10.1038/hr.2014.173
Resource Type
Thesis or Dissertation
Language
eng
Relation
PMCID: PMC4390453
Resource URL
https://doi.org/10.1038/hr.2014.173
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390453/
Rights
The publisher's final edited version of this article is available at Hypertens Res
Publisher's Version with DOI: https://doi.org/10.1038/hr.2014.173
Text Version
none
Grant ID
博乙第272号
Grant Date
2015-05-27
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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