Effects of diuretics on SGLT2 inhibitor-induced changes in blood pressure in obese rats suffering from the metabolic syndrome

( 最大 2000 件 )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28761
タイトル
Effects of diuretics on SGLT2 inhibitor-induced changes in blood pressure in obese rats suffering from the metabolic syndrome
ファイル
内容記述

Abstract
OBJECTIVE:

Experiments were carried out to investigate whether diuretics (hydrochlorothiazide + furosemide) impact on the effects of a sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor on glucose metabolism and blood pressure (BP) in metabolic syndrome SHR/NDmcr-cp(+/+) rats (SHRcp).
METHODS:

Male 13-week-old SHRcp were treated with: vehicle; the SGLT2-inhibitor luseogliflozin (10 mg/kg per day); diuretics (hydrochlorothiazide; 10 mg/kg/day + furosemide; 5 mg/kg per day); or luseogliflozin + diuretics (n = 5-8 for each group) daily by oral gavage for 5 weeks. BP and glucose metabolism were evaluated by a telemetry system and oral glucose tolerance test, respectively.
RESULTS:

Vehicle-treated SHRcp developed nondipper type hypertension (dark vs. light-period mean arterial pressure: 148.6 ± 0.7 and 148.0 ± 0.7 mmHg, respectively, P = 0.2) and insulin resistance. Compared with vehicle-treated animals, luseogliflozin-treated rats showed an approximately 4000-fold increase in urinary excretion of glucose and improved glucose metabolism. Luseogliflozin also significantly decreased BP and turned the circadian rhythm of BP from a nondipper to dipper pattern (dark vs. light-period mean arterial pressure: 138.0 ± 1.6 and 132.0 ± 1.3 mmHg, respectively, P < 0.01), which were associated with a significant increase in urinary excretion of sodium. Addition of diuretics did not influence luseogliflozin-induced improvement of glucose metabolism and circadian rhythm of BP in SHRcp.
CONCLUSION:

These data suggest that a SGLT2 inhibitor elicits its beneficial effects on glucose metabolism and hypertension in study participants with metabolic syndrome undergoing treatment with diuretics.

Keywords:

diuretics; glucose homeostasis; hypertension; insulin resistance; metabolic syndrome; sodium-dependent glucose cotransporter 2 inhibitor

(医博乙277)

著者
著者 MD. ASADUR RAHMAN
著者(ヨミ) エムディ アサドウール ラフマン
著者(別表記) Rahman Asadur
掲載誌
Journal of Hypertension
掲載誌(別表記)
J Hypertens.
34
5
開始ページ
893
終了ページ
906
出版者
International Society of Hypertension
Wolters Kluwer Health
出版年月日
2016-05
ISSN
0263-6352
NCID
AA10644107
PMID
26982381
DOI
10.1097/HJH.0000000000000871
資料タイプ
学位論文
言語
英語
関連情報URL
https://doi.org/10.1097/HJH.0000000000000871
権利関係
Copyright © 2016 Wolters Kluwer Health, Inc.
"This is the Accepted Version of the following article: Effects of diuretics on sodium-dependent glucose cotransporter 2 inhibitor-induced changes in blood pressure in obese rats suffering from the metabolic syndrome; Journal of Hypertension; Volume 34 - Issue 5 (2016) Pages: 893-906; doi: 10.1097/HJH.0000000000000871, which has been published in final form at https://doi.org/10.1097/HJH.0000000000000871 . "
博士論文(全文を含む)
学位授与番号
博乙第277号
学位授与年月日
2016-03-04
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.