Accumulation of microdamage in subchondral bone at the femoral head in patients with end-stage osteoarthritis of the hip

( 最大 2000 件 )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28763
タイトル
Accumulation of microdamage in subchondral bone at the femoral head in patients with end-stage osteoarthritis of the hip
ファイル
内容記述

Abstract

In end-stage osteoarthritis (OA) of the hip, the effect of bone metabolism with and without cartilage is unclear. In this study, we aimed to investigate histomorphology and microdamage in the subchondral bone of the femoral head in areas with and without articular cartilage in patients with end-stage OA. Nineteen femoral heads were evaluated in 10 women who underwent total hip arthroplasty for OA and in nine cadaveric controls (CNT). Chondral thickness and subchondral bone plate thickness (SBP.Th) were measured in 5-mm-wide areas where cartilage was lost (area A) or preserved (area B) in OA and in corresponding areas in the load-bearing portion of the femoral head in the CNT. Histomorphometry and microdamage in 5 × 5-mm areas of cancellous bone were assessed. SBP.Th and bone volume were significantly greater in area A than in area B or in the CNT. Osteoid volume was significantly greater in area A than in area B or in the CNT. There was no significant difference in eroded surface between area A and CNT. Microcrack density was significantly greater in area A than in area B or in the CNT. Although accumulation of microdamage was caused by concentration of stress on the subchondral bone in the cartilage loss area in end-stage OA, remodeling for microdamage repairing mechanism was not enhanced. It was considered that the subchondral cancellous bone volume was increased because of modeling, not remodeling, by stress concentration due to articular cartilage loss.

KEYWORDS:

Bone microdamage; Bone modeling; Femoral head; Histomorphometry; Osteoarthritis

(医博甲723)

著者
著者 嶌村 将志
著者(ヨミ) シマムラ マサシ
著者(別表記) Shimamura Masashi
掲載誌
Journal of Bone and Mineral Metabolism
掲載誌(別表記)
J Bone Miner Metab.
開始ページ
1
終了ページ
6
出版者
Springer (part of Springer Nature)
出版年月日
2019-01-30
ISSN
0914-8779
NCID
AA10747551
PMID
30701320
DOI
10.1007/s00774-019-00988-z
資料タイプ
学位論文
言語
英語
情報源
https://link.springer.com/article/10.1007/s00774-019-00988-z
関連情報URL
https://doi.org/10.1007/s00774-019-00988-z
https://link.springer.com/article/10.1007/s00774-019-00988-z
権利関係
エンバーゴ期間満了後の2020年1月30日以降に博士論文本文を掲載します。 / The main text of the doctoral dissertation will be published on January 30, 2020, after the expiration of the embargo period.
Copyright © 2019 Springer Nature Switzerland AG. Part of Springer Nature.
"This is the Accepted Version of the following article: Accumulation of microdamage in subchondral bone at the femoral head in patients with end-stage osteoarthritis of the hip; Journal of Bone and Mineral Metabolism; [Epub ahead of print] (2019) Pages: 1-6; doi: 10.1007/s00774-019-00988-z, which has been published in final form at https://doi.org/10.1007/s00774-019-00988-z . "
Springer link: https://link.springer.com/article/10.1007/s00774-019-00988-z
Publisher's Version with DOI: https://doi.org/10.1007/s00774-019-00988-z
該当なし
学位授与番号
博甲第723号
学位授与年月日
2019-06-25
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.