Diagnostic Value of Flow Cytometry Standardized Using the European LeukemiaNet for Myelodysplastic Syndrome
URI | http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28808 | ||||||
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Title |
Diagnostic Value of Flow Cytometry Standardized Using the European LeukemiaNet for Myelodysplastic Syndrome
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Title Alternative |
骨髄異形成症候群の診断におけるELN基準表面マーカーの有用性
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File |
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Description |
Abstract Myelodysplastic syndromes (MDS) and idiopathic cytopenia of undetermined significance (ICUS) are heterogeneous hematological disorders characterized by hematopoietic dysplasia and/or chromosomal aberrancy. This study aimed to evaluate the diagnostic value of flow cytometry standardized using the European LeukemiaNet (ELN) for MDS and ICUS by analyzing samples obtained from patients with cytopenia based on morphological examination, cytogenetic analysis, and flow cytometry. We retrospectively analyzed bone marrow samples aspirated from 253 consecutive patients (median age: 66 years [range: 1-92]) to identify the cause of cytopenia. Sixty patients presented with MDS, and 16 with ICUS. MDS subtypes were distributed as follows: MDS with single-lineage dysplasia (n = 10); MDS with multi-lineage dysplasia (n = 10); MDS with ringed sideroblasts (n = 4); MDS with excess blasts-1 (n = 9); MDS with excess blasts-2 (n = 13), MDS unclassified (n = 5); 5q-syndrome (n = 6); and MDS/myeloproliferative neoplasms (n = 3). Four representative ELN indexes were used. Two or more ELN MDS indexes were in the abnormal range in 35 MDS cases (58.3%) and 4 ICUS cases (25.0%). Morphological examination remains the standard for MDS diagnosis. Considering the low incidence of genetically proven ICUS (20.2-27.5%), the low sensitivity of ELN MDS indexes for ICUS is considered a valuable alternative. KEYWORDS: Cytopenia; Diagnostic index; European LeukemiaNet; Flow cytometry; Myelodysplastic syndrome (医博甲725) |
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Author |
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Publication Title |
Acta haematologica
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Publication Title Alternative |
Acta haematol.
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Start Page |
1
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End Page |
6
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Publisher |
Karger Publishers
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Published Date |
2019-07-22
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ISSN |
1421-9662
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NCID |
AA12780820
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PMID |
31330512
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DOI |
10.1159/000501147
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Resource Type |
Thesis or Dissertation
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Language |
eng
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Relation |
[Epub ahead of print]
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Resource URL |
http://sherpa.ac.uk/romeo/issn/0001-5792/
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Rights |
Copyright © 2019 S. Karger AG, Basel.
"This is the Accepted Version of the following article: Diagnostic Value of Flow Cytometry Standardized Using the European LeukemiaNet for Myelodysplastic Syndrome; Acta haematologica; [Epub ahead of print] (2019) Pages: 1-6; doi: 10.1159/000501147 , which has been published in final form at https://doi.org/10.1159/000501147 . "
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Text Version |
ETD
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Grant ID |
博甲第725号
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Grant Date |
2019-09-25
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Degree Name |
博士(医学)
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Grantor |
香川大学
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Set |
香川大学
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