Diagnostic Value of Flow Cytometry Standardized Using the European LeukemiaNet for Myelodysplastic Syndrome

( 最大 2000 件 )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28808
タイトル
Diagnostic Value of Flow Cytometry Standardized Using the European LeukemiaNet for Myelodysplastic Syndrome
タイトル(別表記)
骨髄異形成症候群の診断におけるELN基準表面マーカーの有用性
ファイル
内容記述

Abstract
BACKGROUND:

Myelodysplastic syndromes (MDS) and idiopathic cytopenia of undetermined significance (ICUS) are heterogeneous hematological disorders characterized by hematopoietic dysplasia and/or chromosomal aberrancy.
OBJECTIVES:

This study aimed to evaluate the diagnostic value of flow cytometry standardized using the European LeukemiaNet (ELN) for MDS and ICUS by analyzing samples obtained from patients with cytopenia based on morphological examination, cytogenetic analysis, and flow cytometry.
METHODS:

We retrospectively analyzed bone marrow samples aspirated from 253 consecutive patients (median age: 66 years [range: 1-92]) to identify the cause of cytopenia.
RESULTS:

Sixty patients presented with MDS, and 16 with ICUS. MDS subtypes were distributed as follows: MDS with single-lineage dysplasia (n = 10); MDS with multi-lineage dysplasia (n = 10); MDS with ringed sideroblasts (n = 4); MDS with excess blasts-1 (n = 9); MDS with excess blasts-2 (n = 13), MDS unclassified (n = 5); 5q-syndrome (n = 6); and MDS/myeloproliferative neoplasms (n = 3). Four representative ELN indexes were used. Two or more ELN MDS indexes were in the abnormal range in 35 MDS cases (58.3%) and 4 ICUS cases (25.0%).
CONCLUSIONS:

Morphological examination remains the standard for MDS diagnosis. Considering the low incidence of genetically proven ICUS (20.2-27.5%), the low sensitivity of ELN MDS indexes for ICUS is considered a valuable alternative.

KEYWORDS:

Cytopenia; Diagnostic index; European LeukemiaNet; Flow cytometry; Myelodysplastic syndrome

(医博甲725)

著者
著者 竹内 彰浩
著者(ヨミ) タケウチ アキヒロ
著者(別表記) Takeuchi Akihiro
掲載誌
Acta haematologica
掲載誌(別表記)
Acta haematol.
開始ページ
1
終了ページ
6
出版者
Karger Publishers
出版年月日
2019-07-22
ISSN
1421-9662
NCID
AA12780820
PMID
31330512
DOI
10.1159/000501147
資料タイプ
学位論文
言語
英語
関連情報
[Epub ahead of print]
関連情報URL
http://sherpa.ac.uk/romeo/issn/0001-5792/
権利関係
Copyright © 2019 S. Karger AG, Basel.
"This is the Accepted Version of the following article: Diagnostic Value of Flow Cytometry Standardized Using the European LeukemiaNet for Myelodysplastic Syndrome; Acta haematologica; [Epub ahead of print] (2019) Pages: 1-6; doi: 10.1159/000501147 , which has been published in final form at https://doi.org/10.1159/000501147 . "
博士論文(全文を含む)
学位授与番号
博甲第725号
学位授与年月日
2019-09-25
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.