Association between carotid 18F-NaF and 18F-FDG uptake on PET/CT with ischemic vascular brain disease on MRI in patients with carotid artery disease

( Max 2000 Items )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28985
Title
Association between carotid 18F-NaF and 18F-FDG uptake on PET/CT with ischemic vascular brain disease on MRI in patients with carotid artery disease
File
Description

Abstract

Objective: Atherosclerosis is a dynamic and complex process characterized by the formation and progression of plaque mediated by various pathophysiologic steps including inflammation and calcification. The present study aimed to evaluate the association between carotid 18F-sodium fluoride (NaF) and 18F-fluorodeoxyglucose (FDG) uptake with the severity of ischemic vascular brain disease on MRI in patients with carotid artery disease.

Methods: A total of 28 patients who were scheduled to undergo clinically indicated carotid endarterectomy or stenting for carotid artery disease were examined with 18F-NaF and 18F-FDG PET/CT and brain MRI. The PET/CT images were evaluated by qualitative and semiquantitative analyses. The maximum standardized uptake value (SUV) for the plaque and the average of mean SUV within the lumen of both internal jugular veins was calculated, and the target-to-blood pool ratio (TBR) was determined. The ischemic vascular brain disease on MRI was graded separately in the bilateral hemisphere as 0, 1, 2, and 3, with 0 being absent and 3 being the most severe.

Results: In two patients, only a unilateral carotid artery was analyzed because of previous indwelling stent. 18F-NaF focal uptake was observed in 50 carotid arteries. 18F-FDG focal uptake was observed in 47 carotid arteries. The mean (± SD) 18F-NaF TBR (2.93 ± 0.89) was significantly higher than the mean (± SD) 18F-FDG TBR (2.41 ± 0.84) (p < 0.001). The mean (± SD) values of 18F-NaF TBR were 2.63 ± 0.76 in grade 1, 2.90 ± 0.91 in grade 2, and 3.81 ± 0.60 in grade 3. Significant differences in 18F-NaF TBR were observed between grades 1 and 3 (p < 0.001) and grades 2 and 3 (p = 0.02). The mean (± SD) values of 18F-FDG TBR were 2.35 ± 0.77 in grade 1, 2.23 ± 0.48 in grade 2, and 2.87 ± 1.32 in grade 3. No significant differences in 18F-FDG TBR were noted between any of the ischemic vascular brain disease grades.

Conclusions: These preliminary results suggest that carotid 18F-NaF uptake in patients with carotid artery disease may be associated with the severity of the ischemic vascular brain disease observed on MRI.

Keywords:

18F-FDG; 18F-NaF; Atherosclerosis; Carotid artery; PET

(医博甲738)

Author
著者 藤本 憲吾
著者(ヨミ) フジモト ケンゴ
著者(別表記) Fujimoto Kengo
Publication Title
Annals of nuclear medicine
Publication Title Alternative
Ann Nucl Med.
Volume
33
Issue
12
Start Page
907
End Page
915
Publisher
Japanese Society of Nuclear Medicine
日本核医学会
Springer
Published Date
2019-12
ISSN
0914-7187
NCID
AA12431785
PMID
31571042
DOI
10.1007/s12149-019-01403-3
Resource Type
Thesis or Dissertation
Language
eng
Resource URL
https://doi.org/10.1007/s12149-019-01403-3
Rights
Copyright © 2020 Springer Nature Switzerland AG. Part of Springer Nature.
Text Version
none
Grant ID
博甲第738号
Grant Date
2020-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.