Effects of an SGLT2 inhibitor on the salt sensitivity of blood pressure and sympathetic nerve activity in a nondiabetic rat model of chronic kidney disease

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28987
Title
Effects of an SGLT2 inhibitor on the salt sensitivity of blood pressure and sympathetic nerve activity in a nondiabetic rat model of chronic kidney disease
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Description

Abstract

The glucose-lowering effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors is reduced in patients with diabetes who have chronic kidney disease (CKD). In the present study, we examined the effect of an SGLT2 inhibitor on the salt sensitivity of blood pressure (BP), circadian rhythm of BP, and sympathetic nerve activity (SNA) in nondiabetic CKD rats. Uninephrectomized Wistar rats were treated with adenine (200 mg/kg/day) for 14 days. After stabilization with a normal-salt diet (NSD, 0.3% NaCl), a high-salt diet (HSD, 8% NaCl) was administered. Mean arterial pressure (MAP) was continuously monitored using a telemetry system. We also analyzed the low frequency (LF) of systolic arterial pressure (SAP), which reflects SNA. In adenine-induced CKD rats, HSD consumption for 5 days significantly increased the mean MAP from 106 ± 2 to 148 ± 3 mmHg. However, MAP was decreased to 96 ± 3 mmHg within 24 h after switching back to a NSD (n = 7). Treatment with an SGLT2 inhibitor, luseogliflozin (10 mg/kg/day, p.o., n = 7), significantly attenuated the HSD-induced elevation of MAP, which was associated with a reduction in LF of SAP. These data suggest that treatment with an SGLT2 inhibitor attenuates the salt sensitivity of BP, which is associated with SNA inhibition in nondiabetic CKD rats.

Keywords:

Blood pressure; Chronic kidney disease; Rat; Salt; Sodium-glucose cotransporter 2 inhibitor; Sympathetic nerve activity

(医博甲740)

Author
著者 WAN NINGNING
著者(ヨミ) ワン ニンニン
著者(別表記) Wan Ningning
Publication Title
Hypertension research
Publication Title Alternative
Hypertens Res.
Publisher
Japanese Society of Hypertension
日本高血圧学会
Springer
Published Date
2020-02-14
ISSN
0916-9636
NCID
AA12022378
PMID
32060381
DOI
10.1038/s41440-020-0410-8
Resource Type
Thesis or Dissertation
Language
eng
Rights
"This is the Accepted Version of the following article: Effects of an SGLT2 inhibitor on the salt sensitivity of blood pressure and sympathetic nerve activity in a nondiabetic rat model of chronic kidney disease; Hypertension research; [Online ahead of print] (2020); doi: 10.1038/s41440-020-0410-8, which has been published in final form at https://doi.org/10.1038/s41440-020-0410-8 . "
Non-commercial use only.
Text Version
none
Grant ID
博甲第740号
Grant Date
2020-03-24
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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