Developmental changes in urinary coproporphyrin ratio in premature infants

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/28988
タイトル
Developmental changes in urinary coproporphyrin ratio in premature infants
ファイル
内容記述

Abstract

Background: Premature infants have a high concentration of conjugated bilirubin in their blood, although they have a poor glucuronide conjugation of bilirubin. This may be due to developmental changes in the function of adenosine triphosphate binding cassette subfamily C member 2, which is involved in the cellular export of conjugated bilirubin. In the present study, we examined the developmental changes in the urinary coproporphyrin I/(urinary coproporphyrin I+ urinary coproporphyrin III) ratio (UCP (I/ [I + III])), a known biomarker for adenosine triphosphate binding cassette subfamily C member 2 function, in premature infants.

Method: Twenty-one premature infants born between 25 and 32 weeks of gestation were included in the study. Urine samples were collected within 24 h of birth, and at 1 week and 3-4 weeks after birth. The samples were analyzed by high-performance liquid chromatography to calculate UCP (I/ [I + III]) to examine its association with postnatal age and corrected gestational age. Subjects were excluded if they had liver dysfunction, cholestasis, urinary tract infection, or chromosomal abnormalities.

Results: The average UCP (I/ [I + III]) within 24 h of birth, at 1 week, and at 3-4 weeks after birth was 0.84, 0.61, and 0.65, respectively. The UCP (I/ [I + III]) within 24 h of birth was significantly higher than that measured at 1 week or 3-4 weeks after birth. There was no significant correlation between UCP (I/ [I + III]) and the corrected gestational age.

Conclusion: The UCP (I/ [I + III]) was higher within 24 h of birth. It decreased 1 week after birth and remained low without any significant changes for up to 4 weeks after birth.

Keywords:

ATP-binding cassette subfamily C member 2; conjugated bilirubin; developmental change; premature infants; urinary coproporphyrin

(医博甲741)

著者
著者 中田 裕生
著者(ヨミ) ナカタ ユウセイ
著者(別表記) Nakata Yusei
掲載誌
Pediatrics international
掲載誌(別表記)
Pediatr Int.
62
1
開始ページ
65
終了ページ
69
出版者
Japan Pediatric Society
日本小児科学会
Wiley
出版年月日
2020-01-19
ISSN
1328-8067
NCID
AA11631585
PMID
31628881
DOI
10.1111/ped.14024
資料タイプ
学位論文
言語
英語
権利関係
Copyright © 2019 Japan Pediatric Society.
"This is the Accepted Version of the following article: Developmental changes in urinary coproporphyrin ratio in premature infants; Pediatrics international; Volume 62 Number 1 (2020) Pages: 65-69; doi: 10.1111/ped.14024, which has been published in final form at https://doi.org/10.1111/ped.14024 . "
該当なし
学位授与番号
博甲第741号
学位授与年月日
2020-03-24
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.