Bone metabolism of the jaw in response to bisphosphonate: A quantitative analysis of bone scintigraphy images

( 最大 2000 件 )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/29003
タイトル
Bone metabolism of the jaw in response to bisphosphonate: A quantitative analysis of bone scintigraphy images
ファイル
内容記述

Abstract

We examined the changes in the bone metabolism of the jaw in response to BP treatment, and we used bone SPECT-CT to analyze the site-specific bone metabolism between the jaw and other sites of bone. We compared the changes in the bone metabolism of each part of bone in response to BP treatment by performing a quantitative analysis of bone scintigraphy images between patients treated with low-dose BP for osteoporosis (LBP group; n = 17), those treated with high-dose BP for metastatic bone tumor (HBP group; n = 11), and patients with other oral disease who required bone scintigraphy, with no history of BP treatment (control group; n = 40). The study endpoint was the mean standardized uptake value (SUV) of the uptake of Tc-99 m methylene diphosphonate (MDP) in each group. The mean SUVs of the HBP group were significantly lower at the axial bone of the cervical vertebra, thoracic vertebra, sternum, and rib compared to those of the LBP and control groups. The LBP group's mean SUV was significantly higher at the temporal bone, the anodontia part of the alveolar bone in maxilla, the vital teeth part of alveolar bone in the mandible, and the temporomandibular joint. There was no significant difference among the three groups at the mandibular angle and mandibular ramus. Our analyses revealed that the bone metabolism of the jaw and temporal bone in the BP-treated patients was enhanced, and no suppression of bone remodeling in the jaw by BP was observed.

Keywords:

Bisphosphonate; Bone metabolism; Bone scintigraphy; Jaw; SUV

(医博甲753)

著者
著者 中井 史
著者(ヨミ) ナカイ フミ
著者(別表記) Nakai Fumi
掲載誌
Odontology
掲載誌(別表記)
Odontology.
出版者
Society of the Nippon Dental University
日本歯科大学歯学会
Springer
出版年月日
2020-03-05
ISSN
1618-1247
NCID
AA11580928
PMID
32140951
DOI
10.1007/s10266-020-00503-1
資料タイプ
学位論文
言語
英語
権利関係
Copyright © 2020 Springer Nature Switzerland AG. Part of Springer Nature.
"This is the Accepted Version of the following article: Bone metabolism of the jaw in response to bisphosphonate: A quantitative analysis of bone scintigraphy images; Odontology; 2020 Mar 5. Online ahead of print; doi:10.1007/s10266-020-00503-1, which has been published in final form at https://link.springer.com/article/10.1007/s10266-020-00503-1 . "
Embergo Expiration Date: 2021 Mar. 5.
該当なし
学位授与番号
博甲第753号
学位授与年月日
2020-06-25
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.