D-Tagatose Effectively Reduces the Number of Streptococcus mutans and Oral Bacteria in Healthy Adult Subjects: a Chewing gum Pilot Study and Randomized Clinical Trial

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/29128
Title
D-Tagatose Effectively Reduces the Number of Streptococcus mutans and Oral Bacteria in Healthy Adult Subjects: a Chewing gum Pilot Study and Randomized Clinical Trial
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Description

Abstract

We examined the effect of D-Tagatose on the growth of oral bacteria including Streptococcus mutans (S. mutans). Saliva collected from 10 healthy volunteers was plated on BHI medium (to culture total oral bacteria) and MBS medium (to culture S. mutans, specifically). Agar plates of BHI or MBS containing xylitol or D-Tagatose were cultured under aerobic or anaerobic conditions. We then counted the number of colonies. In BHI plates containing D-Tagatose, a complete and significant reduction of bacteria occurred under both aerobic and anaerobic conditions. In MSB medium, significant reduction of S. mutans was also observed. We then performed a doubleblind parallel randomized trial with 19 healthy volunteers. They chewed gum containing xylitol, D-Tagatose, or both for 4 weeks, and their saliva was collected weekly and plated on BHI and MSB media. These plates were cultured under anaerobic conditions. Total bacteria and S. mutans were not effectively reduced in either the D-Tagatose or xylitol gum group. However, S. mutans was significantly reduced in volunteers chewing gum containing both D-Tagatose and xylitol. Thus, D-Tagatose inhibited the growth of S. mutans and many types of oral bacteria, indicating that D-Tagatose intake may help prevent dental caries, periodontitis, and many oral diseases.

Keywords:

D-Tagatose; Streptococcus mutans; chewing gum; oral bacteria; xylitol

(医博甲756)

Author
著者 永峰 優一
著者(ヨミ) ナガミネ ユウイチ
著者(別表記) Nagamine Yuichi
Publication Title
Acta medica Okayama
Publication Title Alternative
Acta Med Okayama.
Volume
74
Issue
4
Start Page
307
End Page
317
Publisher
Okayama University Medical School
岡山大学医学部
Published Date
2020-08
ISSN
0386-300X
NCID
AA00508441
PMID
32843762
DOI
10.18926/AMO/60369
Resource Type
Thesis or Dissertation
Language
eng
Rights
Copyright © 2020 Okayama University Medical School.
This is the Publisher's Version of the following article: D-Tagatose Effectively Reduces the Number of Streptococcus mutans and Oral Bacteria in Healthy Adult Subjects: a Chewing gum Pilot Study and Randomized Clinical Trial; Acta medica Okayama; Volume 74 Number 4 (2020) Pages: 307-317; doi: 10.18926/AMO/60369, which has been published in final form at https://doi.org/10.18926/AMO/60369 .
Text Version
ETD
Grant ID
博甲第756号
Grant Date
2020-09-29
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.