D-Tagatose Effectively Reduces the Number of Streptococcus mutans and Oral Bacteria in Healthy Adult Subjects: a Chewing gum Pilot Study and Randomized Clinical Trial

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/29128
タイトル
D-Tagatose Effectively Reduces the Number of Streptococcus mutans and Oral Bacteria in Healthy Adult Subjects: a Chewing gum Pilot Study and Randomized Clinical Trial
ファイル
内容記述

Abstract

We examined the effect of D-Tagatose on the growth of oral bacteria including Streptococcus mutans (S. mutans). Saliva collected from 10 healthy volunteers was plated on BHI medium (to culture total oral bacteria) and MBS medium (to culture S. mutans, specifically). Agar plates of BHI or MBS containing xylitol or D-Tagatose were cultured under aerobic or anaerobic conditions. We then counted the number of colonies. In BHI plates containing D-Tagatose, a complete and significant reduction of bacteria occurred under both aerobic and anaerobic conditions. In MSB medium, significant reduction of S. mutans was also observed. We then performed a doubleblind parallel randomized trial with 19 healthy volunteers. They chewed gum containing xylitol, D-Tagatose, or both for 4 weeks, and their saliva was collected weekly and plated on BHI and MSB media. These plates were cultured under anaerobic conditions. Total bacteria and S. mutans were not effectively reduced in either the D-Tagatose or xylitol gum group. However, S. mutans was significantly reduced in volunteers chewing gum containing both D-Tagatose and xylitol. Thus, D-Tagatose inhibited the growth of S. mutans and many types of oral bacteria, indicating that D-Tagatose intake may help prevent dental caries, periodontitis, and many oral diseases.

Keywords:

D-Tagatose; Streptococcus mutans; chewing gum; oral bacteria; xylitol

(医博甲756)

著者
著者 永峰 優一
著者(ヨミ) ナガミネ ユウイチ
著者(別表記) Nagamine Yuichi
掲載誌
Acta medica Okayama
掲載誌(別表記)
Acta Med Okayama.
74
4
開始ページ
307
終了ページ
317
出版者
Okayama University Medical School
岡山大学医学部
出版年月日
2020-08
ISSN
0386-300X
NCID
AA00508441
PMID
32843762
DOI
10.18926/AMO/60369
資料タイプ
学位論文
言語
英語
権利関係
Copyright © 2020 Okayama University Medical School.
This is the Publisher's Version of the following article: D-Tagatose Effectively Reduces the Number of Streptococcus mutans and Oral Bacteria in Healthy Adult Subjects: a Chewing gum Pilot Study and Randomized Clinical Trial; Acta medica Okayama; Volume 74 Number 4 (2020) Pages: 307-317; doi: 10.18926/AMO/60369, which has been published in final form at https://doi.org/10.18926/AMO/60369 .
博士論文(全文を含む)
学位授与番号
博甲第756号
学位授与年月日
2020-09-29
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.