Time Course Changes in Urinary Angiotensinogen and Circulating N-Terminal Pro-B-Type Natriuretic Peptide in Patients Hospitalized With Acute Heart Failure

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/29129
Title
Time Course Changes in Urinary Angiotensinogen and Circulating N-Terminal Pro-B-Type Natriuretic Peptide in Patients Hospitalized With Acute Heart Failure
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Description

Abstract:

Objective
Home care is important in patients with heart failure (HF) in order to maintain their quality of life. A biomarker that can be measured noninvasively is needed to optimize the home care of patients with HF. Urinary angiotensinogen (uAGT) is an indicator of the intrarenal renin-angiotensin system activity, which may be augmented in HF. We hypothesized that uAGT might be a urinary biomarker in HF.

Methods We measured uAGT by an enzyme-linked immunosorbent assay and uAGT normalized by urinary creatinine (uCr)-designated uAGT/uCr-at admission and discharge in 45 patients hospitalized for HF.

Results
We found that both uAGT/uCr [median (interquartile range): 65.5 (17.1-127.7) μg/g Cr at admission; 12.1 (6.0-37.0) μg/g Cr at discharge; p<0.01] and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels [5,422 (2,280-9,907) pg/mL at admission; 903 (510-1,729) pg/mL at discharge; p<0.01] significantly decreased between admission and discharge along with an improvement in patient's clinical status [New York Heart Association scores: 3 (3-4) at admission; 1 (1-1) at discharge; p<0.01]. The generalized least squares model revealed that the time course changes in uAGT/uCr also correlated with those in NT-proBNP levels between admission and readmission in five patients readmitted for HF.

Conclusion
The results indicated that the time course changes in uAGT/uCr correlated with those in the NT-proBNP levels in patients with HF who showed a clinical improvement. Further investigation and development of a kit for the rapid measurement of uAGT are needed to evaluate the clinical utility of uAGT as a biomarker in HF.

Keywords:

heart failure; renin-angiotensin system; urinary angiotensinogen; N-terminal pro-B-type natriuretic peptide

(医博甲757)

Author
著者 横山 聖太
著者(ヨミ) ヨコヤマ ショウタ
著者(別表記) Yokoyama Shota
Publication Title
Internal Medicine
Publication Title Alternative
Intern Med.
Volume
59
Issue
22
Start Page
2839
End Page
2847
Publisher
Japanese Society of Internal Medicine
日本内科学会
Published Date
2020-11-15
ISSN
0918-2918
NCID
AA12022491
PMID
33191370
DOI
10.2169/internalmedicine.5212-20
Resource Type
Thesis or Dissertation
Language
eng
Rights
Copyright © 2020 by The Japanese Society of Internal Medicine
This is the Accepted Version of the following article: Time Course Changes in Urinary Angiotensinogen and Circulating N-Terminal Pro-B-Type Natriuretic Peptide in Patients Hospitalized With Acute Heart Failure; Internal Medicine; Volume 59 Issue 22 (2020) Pages:2839-2847 ; doi: 10.2169/internalmedicine.5212-20, which has been published in final form at https://doi.org/10.2169/internalmedicine.5212-20 .
Text Version
ETD
Grant ID
博甲第757号
Grant Date
2020-09-29
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.