Time Course Changes in Urinary Angiotensinogen and Circulating N-Terminal Pro-B-Type Natriuretic Peptide in Patients Hospitalized With Acute Heart Failure

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/29129
タイトル
Time Course Changes in Urinary Angiotensinogen and Circulating N-Terminal Pro-B-Type Natriuretic Peptide in Patients Hospitalized With Acute Heart Failure
ファイル
内容記述

Abstract:

Objective
Home care is important in patients with heart failure (HF) in order to maintain their quality of life. A biomarker that can be measured noninvasively is needed to optimize the home care of patients with HF. Urinary angiotensinogen (uAGT) is an indicator of the intrarenal renin-angiotensin system activity, which may be augmented in HF. We hypothesized that uAGT might be a urinary biomarker in HF.

Methods We measured uAGT by an enzyme-linked immunosorbent assay and uAGT normalized by urinary creatinine (uCr)-designated uAGT/uCr-at admission and discharge in 45 patients hospitalized for HF.

Results
We found that both uAGT/uCr [median (interquartile range): 65.5 (17.1-127.7) μg/g Cr at admission; 12.1 (6.0-37.0) μg/g Cr at discharge; p<0.01] and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels [5,422 (2,280-9,907) pg/mL at admission; 903 (510-1,729) pg/mL at discharge; p<0.01] significantly decreased between admission and discharge along with an improvement in patient's clinical status [New York Heart Association scores: 3 (3-4) at admission; 1 (1-1) at discharge; p<0.01]. The generalized least squares model revealed that the time course changes in uAGT/uCr also correlated with those in NT-proBNP levels between admission and readmission in five patients readmitted for HF.

Conclusion
The results indicated that the time course changes in uAGT/uCr correlated with those in the NT-proBNP levels in patients with HF who showed a clinical improvement. Further investigation and development of a kit for the rapid measurement of uAGT are needed to evaluate the clinical utility of uAGT as a biomarker in HF.

Keywords:

heart failure; renin-angiotensin system; urinary angiotensinogen; N-terminal pro-B-type natriuretic peptide

(医博甲757)

著者
著者 横山 聖太
著者(ヨミ) ヨコヤマ ショウタ
著者(別表記) Yokoyama Shota
掲載誌
Internal Medicine
掲載誌(別表記)
Intern Med.
59
22
開始ページ
2839
終了ページ
2847
出版者
Japanese Society of Internal Medicine
日本内科学会
出版年月日
2020-11-15
ISSN
0918-2918
NCID
AA12022491
PMID
33191370
DOI
10.2169/internalmedicine.5212-20
資料タイプ
学位論文
言語
英語
権利関係
Copyright © 2020 by The Japanese Society of Internal Medicine
This is the Accepted Version of the following article: Time Course Changes in Urinary Angiotensinogen and Circulating N-Terminal Pro-B-Type Natriuretic Peptide in Patients Hospitalized With Acute Heart Failure; Internal Medicine; Volume 59 Issue 22 (2020) Pages:2839-2847 ; doi: 10.2169/internalmedicine.5212-20, which has been published in final form at https://doi.org/10.2169/internalmedicine.5212-20 .
博士論文(全文を含む)
学位授与番号
博甲第757号
学位授与年月日
2020-09-29
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.