Hydroxychloroquine modulates elevated expression of S100 proteins in systemic lupus erythematosus

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/29131
Title
Hydroxychloroquine modulates elevated expression of S100 proteins in systemic lupus erythematosus
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Description

Abstract

Objectives: We investigated the effect of hydroxychloroquine (HCQ) on S100A8 and S100A9 serum levels in systemic lupus erythematosus (SLE) patients with low disease activity receiving immunosuppressants.

Methods: SELENA-SLEDAI, Cutaneous Lupus Erythematous Disease Area and Severity Index (CLASI) and serum levels of complement factors, anti-dsDNA antibodies, and white blood cell, lymphocyte, and platelet counts were used to evaluate disease activity, cutaneous disease activity, and immunological activity, respectively. Serum S100A8 and S100A9 were measured at HCQ administration and after 3 or 6 months using ELISA.

Results: S100A8 and S100A9 serum levels were elevated at baseline and the magnitude of decrease from baseline at 3 and 6 months after HCQ administration was greater in patients with renal involvement than in those without (baseline: S100A8, p = 0.034; S100A9, p = 0.0084; decrease: S100A8, p = 0.049; S100A9, p = 0.023). S100 modulation was observed in patients with (n = 17; S100A8, p = 0.0011; S100A9, p = 0.0002) and without renal involvement (n = 20; S100A8, p = 0.0056; S100A9, p = 0.0012), and was more apparent in patients with improved CLASI activity scores (improved: S100A8, p = 0.013; S100A9, p = 0.0032; unimproved: S100A8, p = 0.055; S100A9, p = 0.055). No associations were observed for immunological biomarkers.

Conclusion: HCQ may improve organ involvement in SLE by modulating S100 protein levels, especially in patients with renal or skin involvement.

Keywords:

S100A8; S100A9; Systemic lupus erythematosus; hydroxychloroquine; lupus nephritis; skin

(医博乙293)

Author
著者 脇谷 理沙
著者(ヨミ) ワキヤ リサ
著者(別表記) Wakiya Risa
Publication Title
Lupus
Publication Title Alternative
Lupus.
Volume
28
Issue
7
Start Page
826
End Page
833
Publisher
SAGE Publications
Published Date
2019-05-08
ISSN
0961-2033
NCID
AA10837949
PMID
31068068
DOI
10.1177/0961203319846391
Resource Type
Thesis or Dissertation
Language
eng
Rights
Copyright © 2019 SAGE Publications
This is the Accepted Version of the following article: Hydroxychloroquine modulates elevated expression of S100 proteins in systemic lupus erythematosus; Lupus; Volume 28 Number 7 (2019) Pages: 826-833; doi: 10.1177/0961203319846391, which has been published in final form at https://doi.org/10.1177/0961203319846391 .
Text Version
ETD
Grant ID
博乙第293号
Grant Date
2020-09-16
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
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