Hydroxychloroquine modulates elevated expression of S100 proteins in systemic lupus erythematosus

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/29131
タイトル
Hydroxychloroquine modulates elevated expression of S100 proteins in systemic lupus erythematosus
ファイル
内容記述

Abstract

Objectives: We investigated the effect of hydroxychloroquine (HCQ) on S100A8 and S100A9 serum levels in systemic lupus erythematosus (SLE) patients with low disease activity receiving immunosuppressants.

Methods: SELENA-SLEDAI, Cutaneous Lupus Erythematous Disease Area and Severity Index (CLASI) and serum levels of complement factors, anti-dsDNA antibodies, and white blood cell, lymphocyte, and platelet counts were used to evaluate disease activity, cutaneous disease activity, and immunological activity, respectively. Serum S100A8 and S100A9 were measured at HCQ administration and after 3 or 6 months using ELISA.

Results: S100A8 and S100A9 serum levels were elevated at baseline and the magnitude of decrease from baseline at 3 and 6 months after HCQ administration was greater in patients with renal involvement than in those without (baseline: S100A8, p = 0.034; S100A9, p = 0.0084; decrease: S100A8, p = 0.049; S100A9, p = 0.023). S100 modulation was observed in patients with (n = 17; S100A8, p = 0.0011; S100A9, p = 0.0002) and without renal involvement (n = 20; S100A8, p = 0.0056; S100A9, p = 0.0012), and was more apparent in patients with improved CLASI activity scores (improved: S100A8, p = 0.013; S100A9, p = 0.0032; unimproved: S100A8, p = 0.055; S100A9, p = 0.055). No associations were observed for immunological biomarkers.

Conclusion: HCQ may improve organ involvement in SLE by modulating S100 protein levels, especially in patients with renal or skin involvement.

Keywords:

S100A8; S100A9; Systemic lupus erythematosus; hydroxychloroquine; lupus nephritis; skin

(医博乙293)

著者
著者 脇谷 理沙
著者(ヨミ) ワキヤ リサ
著者(別表記) Wakiya Risa
掲載誌
Lupus
掲載誌(別表記)
Lupus.
28
7
開始ページ
826
終了ページ
833
出版者
SAGE Publications
出版年月日
2019-05-08
ISSN
0961-2033
NCID
AA10837949
PMID
31068068
DOI
10.1177/0961203319846391
資料タイプ
学位論文
言語
英語
権利関係
Copyright © 2019 SAGE Publications
This is the Accepted Version of the following article: Hydroxychloroquine modulates elevated expression of S100 proteins in systemic lupus erythematosus; Lupus; Volume 28 Number 7 (2019) Pages: 826-833; doi: 10.1177/0961203319846391, which has been published in final form at https://doi.org/10.1177/0961203319846391 .
博士論文(全文を含む)
学位授与番号
博乙第293号
学位授与年月日
2020-09-16
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.