Intravenous edaravone plus therapeutic hypothermia offers limited neuroprotection in the hypoxic-ischaemic newborn piglet
URI | http://shark.lib.kagawa-u.ac.jp/kuir/metadata/29146 | ||||||
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Title |
Intravenous edaravone plus therapeutic hypothermia offers limited neuroprotection in the hypoxic-ischaemic newborn piglet
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Description |
Abstract Background: Therapeutic hypothermia (TH) is a standard therapy for neonatal hypoxic-ischaemic encephalopathy. One potential additional therapy is the free radical scavenger edaravone (EV; 3-methyl-1-phenyl-2-pyrazolin-5-one). Objectives and methods: This study aimed to compare the neuroprotective effects of edaravone plus therapeutic hypothermia (TH + EV) with those of TH alone after a hypoxic-ischaemic insult in the newborn piglet. Anaesthetized piglets were subjected to 40 min of hypoxia (3-5% inspired oxygen), and cerebral ischaemia was assessed using cerebral blood volume. Body temperature was maintained at 39.0 ± 0.5°C in the normothermia group (NT, n = 8) and at 33.5 ± 0.5°C (24 h after the insult) in the TH (n = 7) and TH + EV (3 mg/kg intravenous every 12 h for 3 days after the insult; n = 6) groups under mechanical ventilation. Results: Five days after the insult, the mean (standard deviation) neurological scores were 10.9 (5.7) in the NT group, 17.0 (0.4) in the TH group (p = 0.025 vs. NT), and 15.0 (3.9) in the TH + EV group. The histopathological score of the TH + EV group showed no significant improvement compared with that of the other groups. Conclusion: TH + EV had no additive neuroprotective effects after hypoxia-ischaemia in neurological and histopathological assessments. Keywords: Edaravone; Hypoxic-ischemic encephalopathy; Piglet; Therapeutic hypothermia (医博甲763) |
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Author |
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Publication Title |
Neonatology
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Publication Title Alternative |
Neonatology.
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Start Page |
1
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End Page |
8
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Publisher |
Karger Publishers
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Published Date |
2020-10-28
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ISSN |
1661-7800
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NCID |
AA12189602
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PMID |
33113527
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DOI |
10.1159/000511085
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Resource Type |
Thesis or Dissertation
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Language |
eng
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Rights |
Copyright © 2020 S. Karger AG, Basel.
This is the Accepted Version of the following article: Intravenous edaravone plus therapeutic hypothermia offers limited neuroprotection in the hypoxic-ischaemic newborn piglet; Neonatology; Online ahead of print (2020) Pages: 1-8; doi: 10.1159/000511085, which has been published in final form at https://doi.org/10.1159/000511085 .
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Text Version |
none
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Grant ID |
博甲第763号
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Grant Date |
2020-12-24
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Degree Name |
博士(医学)
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Grantor |
香川大学
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Set |
香川大学
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