Intravenous edaravone plus therapeutic hypothermia offers limited neuroprotection in the hypoxic-ischaemic newborn piglet

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/29146
タイトル
Intravenous edaravone plus therapeutic hypothermia offers limited neuroprotection in the hypoxic-ischaemic newborn piglet
ファイル
内容記述

Abstract

Background: Therapeutic hypothermia (TH) is a standard therapy for neonatal hypoxic-ischaemic encephalopathy. One potential additional therapy is the free radical scavenger edaravone (EV; 3-methyl-1-phenyl-2-pyrazolin-5-one).

Objectives and methods: This study aimed to compare the neuroprotective effects of edaravone plus therapeutic hypothermia (TH + EV) with those of TH alone after a hypoxic-ischaemic insult in the newborn piglet. Anaesthetized piglets were subjected to 40 min of hypoxia (3-5% inspired oxygen), and cerebral ischaemia was assessed using cerebral blood volume. Body temperature was maintained at 39.0 ± 0.5°C in the normothermia group (NT, n = 8) and at 33.5 ± 0.5°C (24 h after the insult) in the TH (n = 7) and TH + EV (3 mg/kg intravenous every 12 h for 3 days after the insult; n = 6) groups under mechanical ventilation.

Results: Five days after the insult, the mean (standard deviation) neurological scores were 10.9 (5.7) in the NT group, 17.0 (0.4) in the TH group (p = 0.025 vs. NT), and 15.0 (3.9) in the TH + EV group. The histopathological score of the TH + EV group showed no significant improvement compared with that of the other groups.

Conclusion: TH + EV had no additive neuroprotective effects after hypoxia-ischaemia in neurological and histopathological assessments.

Keywords:

Edaravone; Hypoxic-ischemic encephalopathy; Piglet; Therapeutic hypothermia

(医博甲763)

著者
著者 山戸 聡史
著者(ヨミ) ヤマト サトシ
著者(別表記) Satoshi Yamato
掲載誌
Neonatology
掲載誌(別表記)
Neonatology.
開始ページ
1
終了ページ
8
出版者
Karger Publishers
出版年月日
2020-10-28
ISSN
1661-7800
NCID
AA12189602
PMID
33113527
DOI
10.1159/000511085
資料タイプ
学位論文
言語
英語
権利関係
Copyright © 2020 S. Karger AG, Basel.
This is the Accepted Version of the following article: Intravenous edaravone plus therapeutic hypothermia offers limited neuroprotection in the hypoxic-ischaemic newborn piglet; Neonatology; Online ahead of print (2020) Pages: 1-8; doi: 10.1159/000511085, which has been published in final form at https://doi.org/10.1159/000511085 .
該当なし
学位授与番号
博甲第763号
学位授与年月日
2020-12-24
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.