18F-FDG PET/CT in patients with polymyositis/dermatomyositis: correlation with serum muscle enzymes

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URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/29147
Title
18F-FDG PET/CT in patients with polymyositis/dermatomyositis: correlation with serum muscle enzymes
File
Description

Abstract

Background

Muscle enzymes are the major noninvasive diagnostic parameters useful in polymyositis/dermatomyositis (PM/DM). Few studies have yet correlated findings on 18F-FDG PET with disease activity in patients with PM/DM.
Purpose

We evaluated 18F-FDG muscle uptake in patients with PM/DM compared with non-muscular diseases and correlated the results with serum muscle enzymes.
Methods

A total of 28 patients with untreated PM/DM and 28 control patients with non-muscular diseases were examined with 18F-FDG PET/CT. 18F-FDG uptake was evaluated in 9 proximal skeletal muscle regions bilaterally. The uptake was scored as follows: 0 = less than that of the mediastinal blood vessels, 1 = greater than or equal to that of the mediastinal blood vessels, and 2 = greater than or equal to that of the liver. A score 1 or 2 was considered positive. The mean and maximum standardized uptake values (SUV) were calculated in each muscle and were averaged for all muscle regions. PET findings were correlated with serum muscle enzymes.
Results

18F-FDG uptake was observed in 82% of patients with PM/DM and 7% of control patients. The number of positive regions, total score, mean SUVmean, and mean SUVmax in patients with PM/DM were significantly higher than those in the control patients (all P < 0.001). The total score of 2 was the best cut-off value that could discriminate patients with PM/DM from control patients. The total score, mean SUVmean, and mean SUVmax showed significant correlations with creatine kinase (P = 0.047, 0.002, 0.010, respectively) and aldolase (P = 0.036, 0.005, 0.038, respectively).
Conclusion

18F-FDG PET/CT using visual and SUV methods demonstrated its usefulness by discriminating PM/DM from non-muscular diseases and correlating with serum muscle enzymes in patients with PM/DM.

Keywords:

18F-FDG; PET; Polymyositis; Dermatomyositis

(医博乙294)

Author
著者 奥田 花江
著者(ヨミ) オクダ ハナエ
著者(別表記) Hanae Okuda
Publication Title
European Journal of Hybrid Imaging
Publication Title Alternative
Eur J Hybrid Imaging.
Volume
4
Start Page
14
End Page
14
Publisher
European Association of Nuclear Medicine
SpringerOpen
Published Date
2020-08-12
ISSN
2510-3636
DOI
10.1186/s41824-020-00084-w
Resource Type
Thesis or Dissertation
Language
eng
Rights
Copyright © 2020 The Authors.
This is the Publisher's Version of the following article: 18F-FDG PET/CT in patients with polymyositis/dermatomyositis: correlation with serum muscle enzymes; European Journal of Hybrid Imaging ; Volume 4 Article number 14 (2020) doi: 10.1186/s41824-020-00084-w, which has been published in final form at https://doi.org/10.1186/s41824-020-00084-w .
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Text Version
ETD
Grant ID
博乙第294号
Grant Date
2020-12-16
Degree Name
博士(医学)
Grantor
香川大学
Set
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.