18F-FDG PET/CT in patients with polymyositis/dermatomyositis: correlation with serum muscle enzymes

( 最大 2000 件 )
URI http://shark.lib.kagawa-u.ac.jp/kuir/metadata/29147
タイトル
18F-FDG PET/CT in patients with polymyositis/dermatomyositis: correlation with serum muscle enzymes
ファイル
内容記述

Abstract

Background

Muscle enzymes are the major noninvasive diagnostic parameters useful in polymyositis/dermatomyositis (PM/DM). Few studies have yet correlated findings on 18F-FDG PET with disease activity in patients with PM/DM.
Purpose

We evaluated 18F-FDG muscle uptake in patients with PM/DM compared with non-muscular diseases and correlated the results with serum muscle enzymes.
Methods

A total of 28 patients with untreated PM/DM and 28 control patients with non-muscular diseases were examined with 18F-FDG PET/CT. 18F-FDG uptake was evaluated in 9 proximal skeletal muscle regions bilaterally. The uptake was scored as follows: 0 = less than that of the mediastinal blood vessels, 1 = greater than or equal to that of the mediastinal blood vessels, and 2 = greater than or equal to that of the liver. A score 1 or 2 was considered positive. The mean and maximum standardized uptake values (SUV) were calculated in each muscle and were averaged for all muscle regions. PET findings were correlated with serum muscle enzymes.
Results

18F-FDG uptake was observed in 82% of patients with PM/DM and 7% of control patients. The number of positive regions, total score, mean SUVmean, and mean SUVmax in patients with PM/DM were significantly higher than those in the control patients (all P < 0.001). The total score of 2 was the best cut-off value that could discriminate patients with PM/DM from control patients. The total score, mean SUVmean, and mean SUVmax showed significant correlations with creatine kinase (P = 0.047, 0.002, 0.010, respectively) and aldolase (P = 0.036, 0.005, 0.038, respectively).
Conclusion

18F-FDG PET/CT using visual and SUV methods demonstrated its usefulness by discriminating PM/DM from non-muscular diseases and correlating with serum muscle enzymes in patients with PM/DM.

Keywords:

18F-FDG; PET; Polymyositis; Dermatomyositis

(医博乙294)

著者
著者 奥田 花江
著者(ヨミ) オクダ ハナエ
著者(別表記) Hanae Okuda
掲載誌
European Journal of Hybrid Imaging
掲載誌(別表記)
Eur J Hybrid Imaging.
4
開始ページ
14
終了ページ
14
出版者
European Association of Nuclear Medicine
SpringerOpen
出版年月日
2020-08-12
ISSN
2510-3636
DOI
10.1186/s41824-020-00084-w
資料タイプ
学位論文
言語
英語
権利関係
Copyright © 2020 The Authors.
This is the Publisher's Version of the following article: 18F-FDG PET/CT in patients with polymyositis/dermatomyositis: correlation with serum muscle enzymes; European Journal of Hybrid Imaging ; Volume 4 Article number 14 (2020) doi: 10.1186/s41824-020-00084-w, which has been published in final form at https://doi.org/10.1186/s41824-020-00084-w .
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
博士論文(全文を含む)
学位授与番号
博乙第294号
学位授与年月日
2020-12-16
学位名
博士(医学)
学位授与機関
香川大学
区分
香川大学
Copyright (C) 2009 Kagawa University All rights reserved.